60K gelatinase in involuting rat mammary gland is produced as a 90K proenzyme
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چکیده
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Apoptosis and autophagy in involuting bovine mammary gland.
Successful lactation depends on a controlled process of cell proliferation and mammary gland growth during pregnancy and cell death during involution. The main type of cell death responsible for involution of bovine mammary gland is apoptosis, but programmed cell death type II (PCD II)--autophagic cell death is also observed. The regulation of mammary epithelial cells (MEC) apoptosis occurs at ...
متن کاملHormonal control of insulin-like growth factor-binding protein-5 production in the involuting mammary gland of the rat.
We have demonstrated a 50-fold increase in the concentration of insulin-like growth factor-binding protein-5 (IGFBP-5) in milk after 2 days of mammary involution induced by removal of the suckling young. IGFBP-5 was identified by its immunoreactivity with an antiserum to IGFBP-5 and was shown by in situ hybridization to be synthesized by the secretory epithelial cells undergoing apoptosis. Smal...
متن کاملCleavage of Histone 3 by Cathepsin D in the Involuting Mammary Gland
The post-lactational regression of mammary gland is a complex multi-step process designed to conserve the biological function of the gland for next pregnancy. This developmental stage is a biological intrigue with great relevance to breast cancer research, and thus has been the subject of intensive scrutiny. Multipronged studies (microarray, proteomics profiling, animal knock-out models) have p...
متن کاملHistological Changes in the Pregnant, Lactating and Involuting Mammary Gland of the Guinea Pig
The histological changes of mammary glands ofguinea pigs during mid and late pregnancy, 1 day after parturition, peak lactation and 2, 3, 4, 8 and 12 days after weaning were studied. Rapid growth of the glandular tzssue occurred towards late pregnancy and was completed by peak lactation. Plasma cells occurred in large numbers in the interalveolar connective tzssue during the period between mid-...
متن کاملGlucose transporter expression in rat mammary gland.
The expression of different glucose transporter isoforms was measured during the development and differentiation of the rat mammary gland. Before conception, when the mammary gland is mainly composed of adipocytes, Glut 4 and Glut 1 mRNAs and proteins were present. During pregnancy, the expression of Glut 4 decreased progressively, whereas that of Glut 1 increased. In the lactating mammary glan...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 1998
ISSN: 1521-6543
DOI: 10.1080/15216549800202772